[Indices of T-lymphocytes and their subpopulations in children with influenza].

The results of the study of T lymphocytes and their subpopulations in 150 children ranging in age from 2 months to 5 years suffering from influenza complicated with croup, pneumonia, and obstructive syndrome are presented. In 47 children, mixed infection: influenza with concomitant adenovirus infection or respiratory-syncytial infection was observed. The control group consisted of 22 normal children.

[Natural killers and interferon in complicated influenza and other acute respiratory viral diseases in children].

The results of the study on the functional activity of natural killers (NK) and serum interferon in 118 children ranging in age from 3 months to 5 years suffering from influenza and other acute respiratory viral diseases complicated with croup, pneumonia, and obstructive syndrome (66 children with influenza, 21 with parainfluenza, 16 with adenovirus infection, and 15 with respiratory syncytial virus diseases) are presented. The control group consisted of 22 normal children. Decreased NK activity was demonstrated in the acute period of all ARVD but was more marked in adenovirus disease and complications with pneumonia, bronchiolitis, obstructive syndrome.

[Antiviral and therapeutic action of protease inhibitors in viral infections: experimental and clinical observations].

The effect of protease inhibitors (gordox, contrycal, epsilon-aminocapronic acid) on the development of influenza virus-induced infectious process was studied. Administration of the above-mentioned drugs exerted a marked antiviral and therapeutic effect both in animal experiments and in treatment of children suffering from influenza. Electron microscopic examinations of lungs from influenza virus-infected animals treated with protease inhibitors revealed definite decrease in the number of virus particles and significant diminution of pathological lesions; the changes were noted which indicated activation of the body immune response.