[Persistent viruses in serological diagnosis of HIV infection].

Specific antibodies to persistent viruses (CMV, EBV, HBV) were detected by ELISA in groups of HIV-infected patients and persons showing indefinite results of the immunoblotting test for HIV-1 antigens, on the one hand, and in HIV-seronegative donors and patients with clinical manifestations of viral infection (CMVI) on the other. The findings indicate that the persons with indefinite immunoblotting test results show elevated blood CMV and HBV antigen levels than in the matched group of seronegative donors. This fact suggests that persistent viral infections might involve in the formation of an indefinite pattern when the sera were tested for HIV.

[A study of sera positive and doubtful for antibodies to the human immunodeficiency virus for the presence of HTLV-I-specific antibodies].

The results of examinations for the presence of antibody to HTLV-I of 205 sera which were positive or indefinite (doubtful) with regard to HIV are presented. No evidence indicating simultaneous infection with HIV and HTLV-I viruses in 18 HIV-positive subjects was obtained. Antibodies to gag-proteins p19 and p28 HTLV-I were detected in one serum showing primary reactivity in screening for HIV antibodies.

[Disorders of the immune system in benign lesions and cancer of the breast].

Immunologic vigor was studied in 225 cases of breast cancer at various stages, 99 patients with benign lesions of the breast and 154 healthy donors. The parameters of cell-mediated immunity under study included total, active and neuraminidase T-lymphocyte levels, concentration of T-lymphocyte subsets (Tm, T gamma, theophylline--sensitive and theophylline--resistant) and their profile, functional activity of lymphocytes in blastogenic reaction with PHA and natural killer levels. Also, such humoral immunity indexes as B-lymphocytes and immunoglobulins A, M and C were evaluated.

[Disorders of immune homeostasis in patients with tumors of the gastrointestinal tract].

To study immune homeostasis status and to improve the diagnostic value of immunological tests in healthy donors and patients with benign and malignant gastrointestinal tumors, 13 clinico-immunological parameters were identified and measured simultaneously in most of the examinees. A new method of analysis of clinico-immunological information based on stage-by-stage visual evaluation of data shown on dispersion programs and identification of areas corresponding to "normal" immune homeostasis is suggested. Data obtained simultaneously from blastogenic reaction of lymphocytes, cytotoxic test for levels of natural killers in blood and tests for determining subpopulational levels of T-lymphocytes were shown to be diagnostically valuable.