Adjuvant PD-1 Blockade With Camrelizumab for Nasopharyngeal Carcinoma: The DIPPER Randomized Clinical Trial.

Importance: Approximately 20% to 30% of patients with locoregionally advanced nasopharyngeal carcinoma (NPC) experience disease relapse despite definitive chemoradiotherapy. The programmed cell death 1 (PD-1) blockade camrelizumab has demonstrated considerable value in recurrent or metastatic NPC, while its role in locoregionally advanced NPC is unclear.

Objective: To evaluate the efficacy and safety of adjuvant camrelizumab for patients with locoregionally advanced NPC.

High sperm DNA stainability might not be an accurate predictive indicator of male fertility and assisted reproductive technology outcomes.

Background: The clinical need for assisted reproduction continued to increase, so did the need for predictive markers of assisted reproductive technology (ART) outcomes. Among all the markers, sperm DNA integrity was paid more and more attention in the assessment of male fertility in recent years, but its clinical value remains still in doubt.

Methods: We conducted a retrospective cohort study.

Redefining Roles-Fathers Play a Crucial Role in Shaping Children's Healthy Eating Behaviors: Cross-Sectional Observational Study.

Background/objectives: Fathers have been largely understudied in feeding research, as most studies have focused on mothers. This study aims to explore the relationship between paternal feeding practices and child eating behaviors.

Methods: This study employed a cross-sectional observational design.

β-Ionone Treatment Enhances the Antioxidant Capacity in Postharvest Broccoli ( L. var. ) by Maintaining the Levels of Bioactive Substances.

Broccoli is prone to nutrient loss during postharvest storage due to its high respiratory metabolism. In this study, we investigated the effects of 0.1 mm β-ionone on bioactive substances and antioxidant capacity during postharvest storage of broccoli.

Changes in Mitochondrial Transcriptional Rhythms and Depression-like Behavior in the Hippocampus of IL-33-Overexpressing Mice.

Neuroinflammation is involved in the development of depression and may induce depression-like behaviors by affecting metabolism through interactions with circadian rhythms. As the hub of metabolism, mitochondria are regulated by various types of metabolism and release signals that regulate cellular functions. In this study, we performed transcriptomic analysis of the hippocampus of IL-33-overexpressing mice to provide new ideas to explore the pathogenesis of inflammation-mediated depression at the transcriptional level.