SAFETY AND EFFICACY OF THE COMPLEX DEPRILIUM® IN REDUCING SUBCLINICAL SYMPTOMS OF DEPRESSION IN PATIENTS WITH CHRONIC NON-COMMUNICABLE DISEASES: DOUBLE-BLIND RANDOMIZED CONTROLLED STUDY.

Objective: The aim: To evaluate the effectiveness of the use of the Deprilium® complex for the relief of subclinical symptoms of depression in patients with NCD.

Patients And Methods: Materials and methods: There were 140 patients involved in the study. To assess the subclinical symptoms, the Hamilton Depression Rating Scale (HAM-D) was used.

DEVELOPMENT OF ANOREXIA NERVOSA IN A FEMALE ADOLESCENT IN A DYSFUNCTIONAL FAMILY ENVIRONMENT WITH IMPAIRED ATTACHMENT AND EMOTIONAL REGULATION: A CASE REPORT.

A 17-year-old female patient was admitted to the psychoneurological department of Kyiv Clinical Railway Hospital No. 1, due to deterioration of her mental state, a significant decrease in body weight, and no effect of outpatient treatment. The complex treatment program, directed on the correction of all multidimensional disorders with the preliminary psychodiagnostics examination of the patient and her parents according to the FACES-III, DERS, which were monitored in dynamics during the 3,6,9 and 12 months of treatment, was applied.

Gene by environment interaction mouse model reveals a functional role for 5-hydroxymethylcytosine in neurodevelopmental disorders.

Mouse knockouts of show altered neurodevelopmental behavior, deficits in striatal GABAergic signaling, and a genome-wide disruption of an environmentally sensitive DNA methylation modification (5-hydroxymethylcytosine [5hmC]) in the orthologs of a significant number of genes implicated in human neurodevelopmental disorders. We tested adult heterozygous mice ( ; lacking behavioral or neuropathological abnormalities) subjected to a prenatal stress and found that prenatally stressed female mice show repetitive behaviors and altered sociability, similar to the homozygote phenotype. Genomic profiling revealed disruptions in hippocampal and striatal 5hmC levels that are correlated to altered transcript levels of genes linked to these phenotypes (e.