Leishmaniasis in Patients With Inflammatory Bowel Disease: A National Multicenter Study of GETECCU.

Background: Leishmaniasis (LI) is a vector-borne illness caused by a protozoan of the genus Leishmania. Data on the features of LI in patients with inflammatory bowel disease (IBD) are scarce.

Aim: To describe the characteristics of patients with IBD who present with leishmaniasis, infection outcomes and the risk factors associated with developing visceral leishmaniasis (VL).

A Robust and Sensitive New Peak Detection and Identification Method for Mass Spectrometry-Based Differential Analysis in Biologics Characterization.

New peak detection (NPD) is a significant component of the multiattribute method (MAM) for MS use to facilitate the detection of quality attributes exhibiting abnormal ratio changes, vanishing attributes, or newly emerging attributes. However, challenges remain to get a balanced sensitivity and minimize false positives in NPD. In this study, we have developed a robust NPD and identification method to enhance sensitivity 10-fold (0.

Dynamics of thrombin generation: Filling the gap between the system pharmacology theory and clinical practice in clinical pharmacology and therapeutics.

Mathematical models of thrombin generation (TG) that have been developed are based on a systems biology approach. Although this approach provides important information about the coagulation system, its clinical applicability is limited by its complexity and number of input variables required. The aim of this study was to develop a semimechanistic model able to describe TG in trauma and control patients.

Modelling indoor radical chemistry during the HOMEChem campaign.

In the indoor environment, occupants are exposed to air pollutants originating from continuous indoor sources and exchange with the outdoor air, with the highest concentration episodes dominated by activities performed indoors such as cooking and cleaning. Here we use the INdoor CHEMical model in Python (INCHEM-Py) constrained by measurements from the House Observations of Microbial and Environmental Chemistry (HOMEChem) campaign, to investigate the impact of a bleach cleaning event and cooking on indoor air chemistry. Measurements of the concentrations of longer-lived organic and inorganic compounds, as well as measured photolysis rates, have been used as input for the model, and the modelled hydroxyl (OH) radicals, hydroperoxyl radicals, and nitrous acid (HONO) concentrations compared to the measured values.