Publications by authors named "L P Perrault"
Coronary artery disease (CAD) is more prevalent in men than in women, with endothelial dysfunction, prodromal to CAD, developing a decade earlier in middle-aged men. We investigated the molecular basis of this dimorphism ex vivo in arterial segments discarded during surgery of CAD patients. The results reveal a lower endothelial relaxant sensitivity in men, and a senescence-associated inflammaging transcriptomic signature in endothelial cells.
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- The analysis aimed to compare patient outcomes from two large cohorts in Europe and the USA who underwent coronary artery bypass grafting (CABG) to assess the effectiveness of knowledge exchange among cardiovascular surgery societies.
- Data was collected from the European DuraGraft Registry (2,522 patients) and the US STS database (294,725 patients), with both groups undergoing CABG between 2016 and 2019, and factors were matched using propensity score models to ensure fair comparison of outcomes.
- Key findings revealed different patient profiles, with European patients more likely to have left main disease and receive arterial grafts, while US patients tended to have more saphenous vein grafts; however, these differences in treatment approaches were
While voltage-gated potassium channels have critical roles in controlling neuronal excitability, they also have non-ion-conducting functions. Kv8.1, encoded by the KCNV1 gene, is a 'silent' ion channel subunit whose biological role is complex since Kv8.
View Article and Find Full Text PDFBackground: Postoperative atrial fibrillation (POAF) is associated with increased morbidity and mortality. Epicardial injection of botulinum toxin may suppress POAF.
Objectives: This study sought to assess the safety and efficacy of AGN-151607 for the prevention of POAF after cardiac surgery.