Merkel cell polyomavirus pan-T antigen knockdown reduces cancer cell stemness and promotes neural differentiation independent of RB1.

Merkel cell carcinoma (MCC) is a highly aggressive skin cancer associated with integration of Merkel cell polyomavirus (MCPyV). MCPyV-encoded T-antigens (TAs) are pivotal for sustaining MCC's oncogenic phenotype, i.e.

Therapy-Associated Polyposis, Late Presentation of a Childhood-Treated Disease.

Therapy-associated polyposis (TAP), an acquired gastrointestinal polyposis in childhood cancer survivors, poses diagnostic challenges resembling hereditary syndromes. Four TAP patients were studied, revealing upper gastrointestinal lesions after radiotherapy in 2 patients, managed by endoscopic resection. Two underwent total colectomy; 1 had adenocarcinoma from a polyp.

A systematic approach to the modelling and comparison of the geometries of spherical electrodes in inertial electrostatic confinement fusion devices.

Inertial electrostatic confinement fusion (IECF) devices often use two concentric spherical electrodes to converge ions in a plasma electrostatically. Using a highly transparent inner cathode, the ions can move through the cathode and collide at the center to undergo fusion reactions. This is a simple method to build a neutron source.