Publications by authors named "L P Milligan"
Background: Trace amine-associated receptor 1 (TAAR1) agonists offer a new approach, but there is uncertainty regarding their effects, exact mechanism of action and potential role in treating psychosis.
Aims: To evaluate the available evidence on TAAR1 agonists in psychosis, using triangulation of the output of living systematic reviews (LSRs) of animal and human studies, and provide recommendations for future research prioritisation.
Method: This study is part of GALENOS (Global Alliance for Living Evidence on aNxiety, depressiOn and pSychosis).
Background: Trace amine-associated receptor 1 (TAAR1) agonism shows promise for treating psychosis, prompting us to synthesise data from human and non-human studies.
Methods: We co-produced a living systematic review of controlled studies examining TAAR1 agonists in individuals (with or without psychosis/schizophrenia) and relevant animal models. Two independent reviewers identified studies in multiple electronic databases (until 17.
Article Synopsis
- Anhedonia, a significant symptom of depression, is being explored as a target for new personalized treatments, particularly through enhancing dopaminergic pathways.
- The study will involve detailed searches for clinical and animal studies on pro-dopaminergic interventions affecting anhedonia, with independent reviewers managing data selection and extraction.
- Outcomes will include overall symptoms of anhedonia and side effects, with plans to update the findings every six months and collaborate with various stakeholders for comprehensive input.
Article Synopsis
- Digital approaches are seen as valuable in addressing the mental health needs of individuals with schizophrenia and severe mental illness, and an international group was formed to discuss challenges and solutions in this area.
- The group identified four main challenges: user involvement, methodological issues, regulatory and funding hurdles, and real-world implementation, and provided specific examples and recommendations for each.
- The consensus includes calls for improved digital mental health research standards, the importance of social factors, and integrating lived experiences into the design and delivery of mental health interventions.