Publications by authors named "L P Mai"

Bottom-up syntheses of carbon nanodots (CND) using solvothermal treatment of citric acid are known to afford nanometer-sized, amorphous polycitric acid-based materials. The addition of suitable co-reactants in the form of in-situ synthesized N-hetero-π-conjugated chromophores facilitates hereby the overall functionalization. Our incentive was to design a CND model that features phenazine (P-CND) - a well-known N-hetero-π-conjugated chromophore - to investigate the influence of the CND matrix on its redox chemistry as well as photochemistry.

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Article Synopsis
  • The research focuses on improving the capacity and stability of layered transition metal oxides by using a dual doping strategy with Mg ions and vacancies.
  • The introduction of these dopants enhances the anionic redox reaction by creating nonbonding O 2p orbitals and prevents structural issues caused by Na-O configurations.
  • The addition of Mn ions stabilizes the structure by preventing the gliding motion of layers during high discharge, resulting in a better-performing electrode for sodium storage.
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There is a lack of an effective prognostic model for predicting outcomes in patients with primary pulmonary hypertension (PPH). A retrospective analysis was conducted on PPH patients from MIMIC and eICU databases. A predictive model was developed to assess mortality risk.

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A comprehensive computational strategy that combined QSAR modelling, molecular docking, and ADMET analysis was used to discover potential inhibitors for β-secretase 1 (BACE-1). A dataset of 1,138 compounds with established BACE-1 inhibitory activities was used to build a QSAR model using mol2vec descriptors and support vector regression. The obtained model demonstrated strong predictive performance (training set:  = 0.

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Article Synopsis
  • The recovery patterns following intracerebral hemorrhage (ICH) are distinct from those of ischemic stroke, featuring a unique timeline for functional improvements.
  • Research shows that ICH recovery usually starts slowly in the initial weeks, with significant gains often seen within the first three months, followed by more gradual progress up to six months and beyond.
  • Understanding these specific recovery trajectories is essential for providing better prognosis, healthcare strategies, and guided interventions in ICH treatment and research.
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