Publications by authors named "L P Karen-Ng"
Oral squamous cell carcinoma (OSCC) is one of the most common malignancies of the head and neck squamous cell carcinoma (HNSCC). HNSCC is recognized as the eighth most commonly occurring cancer globally in men. It is essential to distinguish between cancers arising in the head and neck regions due to significant differences in their etiologies, treatment approaches, and prognoses.
View Article and Find Full Text PDFOral potentially malignant disorders (OPMD) are a group of lesions carrying the risk of developing into cancer. The gold standard to predict which lesions are more likely to undergo malignant transformation is the presence of dysplasia histologically. However, not all dysplastic lesions progress, and non-dysplastic lesions may also undergo malignant transformation.
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- Many established oral epithelial dysplasia (OED) grading criteria are inconsistent and struggle to accurately predict cancer risk, prompting this study to explore if training pathologists could enhance grading reliability.
- A nationwide online calibration exercise revealed significant improvements in inter-observer agreement, especially for the WHO 2017 grading system, showcasing better consistency among pathologists regardless of their years of experience.
- The results highlight the importance of regular calibration training for oral pathologists to ensure better reliability in OED grading, which is crucial for effectively treating oral lesions that may become cancerous.
Head and neck squamous cell carcinoma (HNSCC) is a type of cancer that arises from the epithelium lining of the oral cavity, hypopharynx, oropharynx, and larynx. Despite the advancement of current treatments, including surgery, chemotherapy, and radiotherapy, the overall survival rate of patients afflicted with HNSCC remains poor. The reasons for these poor outcomes are due to late diagnoses and patient-acquired resistance to treatment.
View Article and Find Full Text PDFDyskeratosis Congenita Links Telomere Attrition to Age-Related Systemic Energetics.
J Gerontol A Biol Sci Med Sci
May 2023
The underlying mechanisms of plasma metabolite signatures of human aging and age-related diseases are not clear but telomere attrition and dysfunction are central to both. Dyskeratosis congenita (DC) is associated with mutations in the telomerase enzyme complex (TERT, TERC, and DKC1) and progressive telomere attrition. We analyzed the effect of telomere attrition on senescence-associated metabolites in fibroblast-conditioned media and DC patient plasma.
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