[The search for ways to improve the efficacy of tuberculosis revaccination in children with immunological deficiency].

Clinicoimmunological examination of children to be BCG revaccinated showed 50% of them to have immunodeficiency. Primarily T-cell and macrophagal components of immunity were compromised. The study of immune response to BCG in animals with T-cell and macrophage immunodeficiency validated feasibility of improving antituberculous vaccination efficacy by using thymalin and sodium nucleinate.

[The migration capability of neutrophilic granulocytes in disseminated tuberculosis and sarcoidosis of the lungs].

A method for estimation of neutrophilic granulocyte spontaneous migration in capillaries is suggested. Twenty-one patients with disseminated pulmonary tuberculosis, 19 ones with active pulmonary sarcoidosis, and 30 normal subjects were examined. The findings evidence a higher migration activity of neutrophilic granulocytes in the patients, 66.

[Immunostimulating effect of synthetic surface-active agents in experimental tuberculosis].

The influence of synthetic surfactants of different classes (BX-14, O-14, B-14) on an immunologic reactivity of mice with evolving experimental tuberculosis was studied. The use of the substances leads to an increase of the E-rosette forming cells (E-RFC) in the mice thymus gland and spleen, and stimulates the inhibited function of spleen natural killers, without modifying (except the agent O-14) the cytotoxicity level of thymus gland natural killers. The above substances can enhance the absorbing capacity of the spleen macrophages as well as their ability to reduce nitro blue tetrazolium.