Publications by authors named "L P Finnigan"
Background Emerging evidence suggests mitochondrial dysfunction may play a role in the fatigue experienced by individuals with post-COVID-19 condition (PCC), commonly called long COVID, which can be assessed using MR spectroscopy. Purpose To compare mitochondrial function between participants with fatigue-predominant PCC and healthy control participants using MR spectroscopy, and to investigate the relationship between MR spectroscopic parameters and fatigue using the 11-item Chalder fatigue questionnaire. Materials and Methods This prospective, observational, single-center study (June 2021 to January 2024) included participants with PCC who reported moderate to severe fatigue, with normal blood test and echocardiographic results, alongside control participants without fatigue symptoms.
View Article and Find Full Text PDFMyocardial Disarray and Fibrosis across Hypertrophic Cardiomyopathy Stages Associate with ECG Markers of Arrhythmic Risk.
Eur Heart J Cardiovasc Imaging
October 2024
Article Synopsis
- Myocardial disarray, linked to arrhythmia risk, was studied in patients with prehypertrophic sarcomeric variants (SARC+LVH-) and hypertrophic cardiomyopathy (HCM) using diffusion tensor cardiac MRI (DT-CMR).
- Results showed reduced diastolic fractional anisotropy (FA) and prolonged corrected JT intervals (JTc) in both patient groups compared to controls, suggesting that both conditions exhibit signs of myocardial disarray.
- The study highlighted that lower FA and higher extracellular volume (ECV) correlate with prolonged repolarization, and the JT interval proves effective in distinguishing SARC+LVH- patients from controls and linking to HCM-related sudden cardiac death risk.
Diagnostic utility of electrocardiogram for screening of cardiac injury on cardiac magnetic resonance in post-hospitalised COVID-19 patients: a prospective multicenter study.
Int J Cardiol
November 2024
Article Synopsis
- The study aimed to assess the effectiveness of ECG in detecting cardiac issues in post-hospitalized COVID-19 patients through cardiac magnetic resonance (CMR) imaging.
- Results showed that these patients had significantly more ECG abnormalities compared to healthy controls, yet both groups had similar levels of CMR abnormalities.
- Adding additional analyses on repolarization improved ECG's ability to identify patients with CMR abnormalities and reduced the reliance on sex in the diagnostic process.
Objectives: (i) To monitor cerebral blood flow velocity (CBFv) throughout aortic arch repair surgery and during the recovery period. (ii) To examine the relationship between transcranial doppler ultrasound (TCD) and near-infrared spectroscopy (NIRS) during cardiac surgery. (iii) To examine CBFv in patients cooled to 20°C and 25°C.
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