Publications by authors named "L P Fernando"
Selective binding of small molecule ligands to nucleic acids with high affinity and limited toxicity remains an important goal in the development of compounds that can probe DNA or RNA in cells. Thiazole orange is a cell semi-permeant, fluorescent cyanine dye, with low background noise, that binds several forms of nucleic acids. However, thiazole orange can exhibit cytotoxicity when used at high concentration and/or with prolonged exposure.
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- The systematic literature review aimed to investigate the changes in dengue epidemiology in Sri Lanka from 2000 to 2020.
- The review found that dengue is endemic in Sri Lanka, with significant outbreaks occurring in 2017 and 2019, particularly affecting individuals aged 25-49, and DENV-2 being the most prevalent serotype since 2017.
- The results emphasize the increasing burden of dengue, suggesting a need for improved surveillance, prevention methods, and potential vaccination efforts.
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- Anxiety is a common emotional response to perceived threats, and anxiety disorders are the most widespread psychiatric conditions, often leading to other health issues.
- Research identified a specific group of brainstem neurons, called C1 cells, that are linked to anxiety by influencing behaviors through connections to other brain regions, indicating their role in processing stress and fear.
- Activating C1 cells increased anxiety-like responses, while suppressing their activity reduced stress-related anxiety, suggesting they could be a target for more effective anxiety treatments.
Consumer Out-Of-Pocket Drug Prices Grew Faster Than Prices Faced By Insurers After Accounting For Rebates, 2007-20.
Health Aff (Millwood)
September 2024
The rising price of branded drugs has garnered considerable attention from the public and policy makers. This article investigates the complexities of pharmaceutical pricing, with an emphasis on the overlooked aspects of manufacturer rebates and out-of-pocket prices. Rebates granted by pharmaceutical manufacturers to insurers reduce the actual prices paid by insurers, causing the true prices of prescriptions to diverge from official statistics.
View Article and Find Full Text PDFcauses African trypanosomiasis in humans. Infection with elicits a potent pro-inflammatory immune response within infected human hosts, and this response is thought to at least be partially due to Toll-like receptor (TLR) activation. In response to stimulation by lipopolysaccharide and other pathogen antigens, TLR4 translocates to lipid rafts, which induces the expression of pro-inflammatory genes.
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