As It Is Above, So It Is Below: Repositioning Indigenous Knowledge Systems within Ecosocial Work.

This article explores the development of Indigenous knowledge in relation to the ecosystem and how traditional concepts of planetary well-being can enhance ecosocial work approaches. From an academic point of view, ecosocial work is a unique paradigm that seeks to understand a holistic view of human health, social justice, and environmental sustainability. There is a strong focus on community development in ecosocial work, which is why the profession must be equipped with tools to address the disproportionate impacts of climate change on marginalized groups including refugees and First Nations peoples.

A Pilot Randomized Control Trial of Holding During Hypothermia and Effects on Maternal and Infant Salivary Cortisol Levels.

Background: The lack of physical contact during therapeutic hypothermia (TH) is challenging for parents of newborns with hypoxic ischemic encephalopathy. Holding is often avoided due to concerns for effects on infant temperature and for dislodging equipment.

Purpose: We assessed the effect of holding during TH on maternal and infant salivary cortisol levels and on infant vital signs.

Heterozygous germline TET2 loss-of-function variants associated with an ALPS-like phenotype.

Germline homozygous loss-of-function mutations in TET2 result in significant childhood immunodeficiency that resembles autoimmune lymphoproliferative syndrome and predisposes one to lymphoma. The implications of heterozygous variants are less well understood. We describe four patients with heterozygous germline loss-of-function TET2 mutations who presented with B-cell lymphoma on a background of chronic lymphadenopathy and autoimmune features.

A Drd1-cre mouse line with nucleus accumbens gene dysregulation exhibits blunted fentanyl seeking.

The synthetic opioid fentanyl remains abundant in the illicit drug supply, contributing to tens of thousands of overdose deaths every year. Despite this, the neurobiological effects of fentanyl use remain largely understudied. The nucleus accumbens (NAc) is a central locus promoting persistent drug use and relapse, largely dependent on activity of dopamine D1 receptors.

Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8 T cells with a disease-associated TCR signature.

Immune aplastic anemia (AA) is a life-threatening bone marrow failure disorder driven by an autoimmune T cell attack against hematopoietic stem and progenitor cells (HSPCs). However, the exact autoantigen targets and role of other immune cells in the pathogenesis of AA are unknown. Here, we analyzed a cohort of 218 patients with AA using single-cell RNA and T cell receptor (TCR) αβ sequencing, TCRβ sequencing, flow cytometry, and plasma cytokine profiling.