Publications by authors named "L P Baker"
Introduction: Neighborhood disadvantage may be an important determinant of cardiometabolic health and cognitive aging. However, less is known about relationships among individuals with mild cognitive impairment (MCI).
Methods: The objective of this study is to investigate the relationship between neighborhood disadvantage measured by national Area Deprivation Index (ADI) rank with measures of cardiometabolic health and cognition among Wake Forest (WF) Alzheimer's Disease Research Center (ADRC) participants, with and without MCI.
Article Synopsis
- Estimates indicate significant variation in R&D costs, with 20 large firms comprising 80.8% of patient-months and showing lower costs per patient-month compared to smaller firms.
- A novel methodology was used to analyze R&D costs per drug, focusing on discrete units of activity related to clinical trials and using data from 268 US publicly traded drug developers.
- The study found that R&D costs per new drug averaged around $1.31 billion, with a lower median cost of $708 million, highlighting a skewed distribution of expenses related to drug development.
Data quality for and about American Indian/Alaska Native (AI/AN) people is undermined by deeply entrenched, colonial practices that have become standard in US federal data systems. This article draws on cases of maternal mortality and COVID-19 to demonstrate the ethical and clinical need for inclusive, diverse, and accurate data when researching AI/AN health trends. This article further argues that epidemiologists specifically must challenge implicit bias, question methods and practices, and recognize colonial, racist reporting practices about AI/AN people that have long undermined data collection, analytical, and dissemination practices that are fundamental to epidemiological research.
View Article and Find Full Text PDFBackground: Liver transplantation for unresectable, benign hepatic lesions is rare. Hepatic mesenchymal hamartomas (HMH) are benign, cystic tumors that arise mostly in pediatric populations and can cause compressive symptoms. HMH is rarely associated with placental mesenchymal dysplasia (PMD) and Beckwith-Wiedemann syndrome (BWS).
View Article and Find Full Text PDFUnlabelled: The bacterial genus includes species found in environmental habitats like soil and water, as well as taxa adapted to be host-associated or pathogenic. High genetic diversity may allow for this habitat flexibility, but the specific genes underlying switches between habitats are poorly understood. One lineage of has undergone a substantial habitat change by evolving from a presumed soil-dwelling ancestral state to thrive in floral nectar.
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