Health-Economic Impact Attributable to Occurrence of Pleurisy and Pneumonia Lesions in Finishing Pigs.

Respiratory diseases, such as pleurisy and pneumonia, cause significant health and economic losses in pig production. This study evaluated 867 finishing pigs from a farm with a history of respiratory issues, using macroscopic lesion scoring (SPES and CVPC), histopathological analysis, qPCR diagnostics, and economic modeling. Severe pleurisy (scores 3 and 4) was observed in 42.

Worse lung function, more allergic sensitization but less blood eosinophilia in elderly patients with long-standing versus late-onset asthma.

Background: Asthma in the elderly is usually considered homogeneous and non-atopic.

Objective: To compare clinical, functional and immunological features between elderly asthmatics with long-standing asthma (LSA) and those with late-onset asthma (LOA).

Methods: Eighty-two asthmatics older than 64 were included into LSA (asthma onset before age 40;  = 46) and LOA (asthma onset from 40 years of age on;  = 36) groups.

Colovesical Fistula in a Kidney Transplant Patient: A Fatal Outcome.

Colovesical fistula (CVF) is a rare but potentially serious condition characterized by abnormal communication between the colon and the bladder. This pathology can result from inflammatory diseases, malignancies, or previous surgical interventions, with a significant impact on the patient's quality of life. CVF is associated with high morbidity and mortality rates, particularly in immunosuppressed individuals, such as renal transplant recipients, due to their increased susceptibility to infections and surgical complications.

Selective lysis of acute myeloid leukemia cells by CD34/CD3 bispecific antibody through the activation of γδ T-cells.

Despite the considerable progress in acute myeloid leukemia (AML) treatment, relapse after allogeneic hematopoietic stem cell transplantation (HSCT) is still frequent and associated with a poor prognosis. Relapse has been shown to be correlated with an incomplete eradication of CD34+ leukemic stem cells prior to HSCT. Previously, we have shown that a novel CD34-directed, bispecific T-cell engager (BTE) can efficiently redirect the T-cell effector function toward cancer cells, thus eliminating leukemic cells and .