Publications by authors named "L Ortiz-Alvarez"
Increasing physical activity (PA) is recognised as an efficacious approach for preventing and treating cardiometabolic diseases. Recently, the composition of microorganisms living within the gut has been proposed as an important appropriate target for treating these diseases. Whether PA is related to faecal microbiota diversity and composition in humans remains to be ascertained.
View Article and Find Full Text PDFContext: The endocannabinoid system (ECS) is a signaling system composed of endocannabinoids (eCBs), their receptors, and the enzymes involved in their synthesis and metabolism. Alterations in the ECS are linked to the development of cardiometabolic diseases.
Objective: Here, we investigated the relationship between plasma levels of eCBs and their analogues with body composition and cardiometabolic risk factors.
Article Synopsis
- Gut bacteria help break down bile acids, which are important for digestion, but how they affect human bile levels is not well understood.
- Scientists studied poop samples from 80 young adults to see how the bacteria in their guts related to bile acid levels in their blood.
- They found that certain types of gut bacteria were linked to higher bile acid levels, showing that our gut health might impact digestion, but more research is needed to be sure.
Pre-clinical studies suggest that circulating oxylipins, i.e., the oxidation products of polyunsaturated fatty acids (PUFAs), modulate gut microbiota composition in mice, but there is no information available in humans.
View Article and Find Full Text PDFAcute and long-term exercise differently modulate plasma levels of oxylipins, endocannabinoids, and their analogues in young sedentary adults: A sub-study and secondary analyses from the ACTIBATE randomized controlled-trial.
EBioMedicine
November 2022
Article Synopsis
- This study investigates the role of fatty acid-derived lipid mediators like oxylipins and endocannabinoids in the body's inflammatory and immune responses to exercise stressors, using a randomized controlled trial with sedentary young adults.
- Participants underwent acute endurance and resistance training, followed by a 24-week supervised exercise regimen, with their plasma levels of various lipid mediators measured before and after exercise using advanced mass spectrometry techniques.
- Results showed significant increases (up to 50%) in specific omega-6 and omega-3-derived oxylipins and endocannabinoids after exercise, but the moderate-intensity exercise group experienced a reduction in some omega-6 oxylipins after the