Publications by authors named "L Orellano-Ariza"
Background: In order for cancers to progress, they must evade elimination by CD8 T cells or other immune mechanisms. CD8 T cells recognize and kill tumor cells that display immunogenic tumor peptides bound to MHC I molecules. One of the ways that cancers can escape such killing is by reducing expression of MHC I molecules, and loss of MHC I is frequently observed in tumors.
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- Cancer cells can evade the immune system, particularly CD8 T cells, by reducing MHC I molecule expression, which is critical for T cell recognition and killing of tumor cells.
- This study focuses on the transcription factors IRF1 and IRF2, which regulate MHC I pathway genes, to understand their role in the loss of MHC I expression across various human cancers.
- Findings indicate that reduced IRF2 levels correlate with diminished MHC I expression and that editing IRF2 in melanoma cells leads to decreased recognition by CD8 T cells, highlighting a potential target for improving immunotherapy responses.