Publications by authors named "L Opperman"
Background: The BCG vaccine induces trained immunity, an epigenetic-mediated increase in innate immune responsiveness. Therefore, this clinical trial evaluated if BCG-induced trained immunity could decrease coronavirus disease 2019 (COVID-19)-related frequency or severity.
Methods: A double-blind, placebo-controlled clinical trial of healthcare workers randomized participants to vaccination with BCG TICE or placebo (saline).
Article Synopsis
- - Red wolves are critically endangered, with over 95% living in human care, and gastrointestinal (GI) disease is a major cause of death among them.
- - The study analyzed data from 36 adult red wolves between 2004 and 2022, finding that a diet consisting only of kibble was linked to more severe GI mucosal disease compared to those fed whole prey or meat.
- - It also found that red wolves treated with nonsteroidal anti-inflammatory drugs had worse GI health, while factors like housing and life history had no significant impact.
Introduction: The response to medical management of young dogs with osteoarthritis (OA) associated pain has not been evaluated. Using an open-label design, the effectiveness, over a 4-month period, of standardized management (grapiprant/fish oil/exercise) for treating OA pain in young dogs was evaluated.
Methods: Included dogs were 9 months-4 years of age; ≥3.
This study aimed to determine the prevalence of osteoarthritis (OA) and associated clinical signs in young dogs. Owners of dogs aged 8 months-4 years from a single practice, were contacted in random order, to participate in a general health screen. Clinical and orthopedic examinations were performed.
View Article and Find Full Text PDFPeriodontal mesenchymal stem cells (MSCs) play a crucial role in maintaining periodontium homeostasis and in tissue repair. However, little is known about how periodontal MSCs in vivo respond under periodontal disease conditions, posing a challenge for periodontium tissue regeneration. In this study, Gli1 was used as a periodontal MSC marker and combined with a Gli1-cre ERT2 mouse model for lineage tracing to investigate periodontal MSC fate in an induced periodontitis model.
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