Disease Control and Late Toxicity in Adaptive Dose Painting by Numbers Versus Nonadaptive Radiation Therapy for Head and Neck Cancer: A Randomized Controlled Phase 2 Trial.

Purpose: Local recurrence remains the main cause of death in stage III-IV nonmetastatic head and neck cancer (HNC), with relapse-prone regions within high F-fluorodeoxyglucose positron emission tomography (F-FDG-PET)-signal gross tumor volume. We investigated if dose escalation within this subvolume combined with a 3-phase treatment adaptation could increase local (LC) and regional (RC) control at equal or minimized radiation-induced toxicity, by comparing adaptive F-FDG-PET voxel intensity-based dose painting by numbers (A-DPBN) with nonadaptive standard intensity modulated radiation therapy (S-IMRT).

Methods And Materials: This 2-center randomized controlled phase 2 trial assigned (1:1) patients to receive A-DPBN or S-IMRT (+/-chemotherapy).

A divergent effect of stimulus perceptual details on affective and semantic representations of valence.

The current work investigated the potential dissociation between two modes of valence: affective valence (valence of the emotional response) and semantic valence (stored knowledge about the valence of an object/event). A series of six experiments systematically examined the divergent effect of manipulating the amount of perceptual details on affective valence and semantic knowledge about valence. We predicted that affective valence, more than semantic valence, will be affected by manipulating the amount of stimulus perceptual details.

The effect of relevance appraisal on the emotional response.

Many models of emotion assume that the emotional response is preceded by an assessment of a stimulus' relevance to the perceiver's goals. Although widely assumed, experimentally controlling and, hence, empirically testing the effect of a stimulus' relevance on the emotional response has proven challenging. In this study, we used stimuli with high ecological validity and manipulated their relevance while holding constant the perceptual features of the stimuli.

External partial breast irradiation in prone position: how to improve accuracy?

Introduction: In view of the limited incremental benefit between whole breast irradiation (WBI), accelerated partial breast irradiation (APBI) and omission of radiotherapy in favorable early-stage breast cancer (ESBC), APBI can only be justified if it combines adequate target coverage with the lowest achievable toxicity. Interobserver exercises demonstrated the difficulty of precise target delineation, especially in prone position; information on accuracy is even scarcer. We tested the impact of inserting an additional indicator clip, marking the depth of the tumor in the breast, and the added value of a preoperative CT in treatment position on precision and accuracy.

Late mucosal ulcers in dose-escalated adaptive dose-painting treatments for head-and-neck cancer.

Background: To identify predictive factors for the development of late grade 4 mucosal ulcers in adaptive dose-escalated treatments for head-and-neck cancer.

Material And Methods: Patient data of four dose-escalated three-phase adaptive dose-painting by numbers (DPBN) clinical trials were analyzed in this study. Correlations between the development of late grade 4 ulcers and factors related with the treatment, disease characteristics and the patient were investigated.