Publications by authors named "L Odierna"
Article Synopsis
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Article Synopsis
- Syntaxin1A is organized into nanoclusters, which play a crucial role in the docking and priming of secretory vesicles in neurosecretory cells.
- Researchers used advanced imaging techniques on Drosophila larvae to observe how activity changes the mobility and clustering of syntaxin1A in nerve terminals.
- Results indicate that neurotransmitter release alters syntaxin1A's mobilization by affecting the stability of these nanoclusters, suggesting a dynamic mechanism regulating neurotransmitter release through lateral diffusion and trapping.
We prospectively studied 10 patients with stable exertional ischaemia, selected from a larger group of patients referred for suspected coronary artery disease or to detect residual ischaemia after myocardial infarction, to evaluate pharmacokinetic changes during chronic treatment with gallopamil and its correlation with clinical efficacy in patients with coronary artery disease. Our study consisted of a 1-week run-in single-blind placebo treatment and a 4-week single-blind gallopamil treatment. At the end of the run-in period patients underwent two different exercise tests, the first 2 hours and the second 7 hours after placebo administration.
View Article and Find Full Text PDFWe evaluated the efficacy and safety of gallopamil 150 mg daily in middle-aged and elderly patients with stable exertional ischemia, using a medium-term randomized double-blind cross-over placebo-controlled trial. Twenty middle-aged patients (52.8 +/- 6 years; range 38-61 years) and 14 elderly patients (67.
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