Scarce perinatal social support for women with OUD: Opportunities for doula services.

Problem: Persons with opioid use disorder (OUD) often lack social support, which is associated with improved recovery outcomes.

Background: In the last two decades, the rate of opioid use disorder (OUD) among pregnant people has quadrupled.

Question: This study aimed to describe the prenatal and postpartum social support networks and needs of persons with OUD and assess perceived acceptability of community-based social supports such as doulas.

Genetic variants of thyroxine-binding globulin (TBG).

New genetic variants of decreased TBG binding capacity observed in our studies are described and discussed in relation to previously reported variant types. Although single factor inheritance may explain the strikingly different phenotypes found in X-linked variants it cannot explain the wide variation discerned in the majority of individuals in our control population or the phenomenon of nonpentrance in one of our families. TBG binding capacity may be a polygenic trait with many loci contributing to the observed phenotypes.