Effect of VBIT-4 on the functional activity of isolated mitochondria and cell viability.

VBIT-4 is a new inhibitor of the oligomerization of VDAC proteins of the outer mitochondrial membrane preventing the development of oxidative stress, mitochondrial dysfunction, and cell death in various pathologies. However, as a VDAC inhibitor, VBIT-4 may itself cause mitochondrial dysfunction in healthy cells. The article examines the effect of VBIT-4 on the functional activity of rat liver mitochondria and cell cultures.

Mitochondrial Dyshomeostasis as an Early Hallmark and a Therapeutic Target in Amyotrophic Lateral Sclerosis.

Amyotrophic lateral sclerosis (ALS) is a fatal multisystem disease characterized by progressive death of motor neurons, loss of muscle mass, and impaired energy metabolism. More than 40 genes are now known to be associated with ALS, which together account for the majority of familial forms of ALS and only 10% of sporadic ALS cases. To date, there is no consensus on the pathogenesis of ALS, which makes it difficult to develop effective therapy.

[Methods of art therapy in psychogerontological practice.].

The article deals with the use of art-therapeutic methods in the complex psychological support of the elderly and senile age. The study was conducted on the basis of the Comprehensive Center of Social Services for the Population of the Birsk District and the City of Birsk of the Republic of Bashkortostan and Polyclinic № 1 of Ufa, total sample was 60 respondents aged 60-80 years. The analysis of the results revealed that the use of the art therapy program with the gradual enrichment and complication of art therapy classes stimulates new life orientations, the awareness of the individual of the presence of other psychological characteristics that allow the subject to function successfully in real life.

[Total revascularization of the lower limb in a patient with multifocal atherosclerosis and critical ischaemia].

Described in the article is a clinical case report regarding revascularization of the entire arterial bed of the lower extremity in a male patient presenting with multifocal atherosclerosis, stenoses of the arteries of the iliofemoral segment, occlusions of the superficial femoral artery, popliteal artery and arteries of the crus. Clinically, the patient was diagnosed as having critical ischaemia of the lower limb with wet necrosis of the toes. The patient simultaneously underwent semiclosed loop endarterectomy from the arteries of the femoropopliteal segment with the help of the Vollmar rings, autovenous popliteal-tibial prosthetic repair, as well as exarticulation of the toes.

Interrelation secretory activity of stomach and immunes changes of peripheral blood when ulcerogenesis stomach.

Unlabelled: Incidence of gastric ulcer is high in almost all countries of the world. On the development and course of the disease affect the state acid- and enzymes production stomach, immune status. The purpose was to determine the presence and power of correlative links secretory activity of the stomach and immune changes in the peripheral blood during exacerbation of ulcer disease stomach.