Exploring the safety parameters of ethanolic extract: a step towards harnessing its medicinal potential.

(Sendtn.) D'Arcy, a native plant of the Brazilian Atlantic Forest, has exhibited potential pharmacological effects due to the presence of withanolides with anti-cancer and anti-inflammatory activities. However, there is a lack of research on the safety and toxicity of this plant species.

Behavior Risk Factors for Non-Communicable Diseases and Caries in Adolescents: A Population Study.

Introduction: Caries is the most widespread non-communicable disease (NCD) globally and can predict fatality NCDs in the future, such as diabetes and cardiovascular diseases. Therefore, we hypothesized that the behavioral risk factors for those NCDs may be present in adolescents with caries.

Objective: To analyze the association of unhealthy diet, tabagism, and alcohol with caries in adolescents.

Mapping physiology: A systems biology approach for the development of alternative methods in toxicology.

Chemical safety assessment still heavily relies on animal testing, presenting ethical dilemmas and limited human predictive value. New approach methodologies (NAMs), including in vitro and in silico techniques, offer alternative solutions. In silico toxicology has made progress in predicting chemical effects but frequently lacks biological mechanistic foundations.

Molar Incisor Hypomineralization and Periodontitis in Adolescents: A Population-Based Study.

Aim: To investigate the association between molar incisor hypomineralization (MIH) and periodontitis in adolescents.

Methods: A population-based study was undertaken of Brazilian adolescents aged 18 and 19 years (n = 2515). MIH was assessed according to Ghanim's criteria.

Structural validity of the Brazilian version of the quality care questionnaire-palliative care for use in individuals with diabetes mellitus eligible for palliative care.

Background: The Brazilian version of the Quality Care Questionnaire-Palliative Care (QCQ-PC) is an instrument designed to assess the quality of care provided in palliative care from the user's perspective, featuring easy comprehension and applicability. It has demonstrated validity for use in individuals with cancer, but there is a need for validation in other populations due to the scarcity of instruments with this purpose.

Objective: To structurally validate the Brazilian version of the QCQ-PC for use in individuals with diabetes mellitus (DM) eligible for palliative care.