[Humoral immune response to structural and nonstructural proteins of tick-borne encephalitis virus in the natural history of the disease].

A hundred and ninety-one patients who had fallen ill with tick-borne encephalitis (TBE) after bites by virus-carrying ticks were examined to reveal the characteristics of antibody production of the major classes of immunoglobulins (IgM and IgG) against structural protein E of the TBE virus and nonstructural protein NS1 of the TBE viral replicative complex in the natural history of an infectious process in different forms and variants of the disease. In the two-wave course of TBE, the infectious process is characterized by a delayed antibody production, lower levels of specific antibodies against virion protein E in the acute phase of disease during the first wave of fever. The development of meningocerebral syndromes at the peak of the second fever wave is observed in patients with the delayed accumulation and low levels of IgG antibodies.

[Evaluation of the effectiveness of various methods of the treatment of tick-borne encephalitis in the acute period].

To reveal the dependence of the efficacy of the treatment of tick-borne encephalitis (TBE) on the patient's HLA phenotype and to elaborate recommendations for individual treatment, 98 subjects who suffered TBE and who received different types of therapy in the acute period (isolated or combined use of specific homologous immunoglobulin and RNase) were subjected to immunogenetic examinations. The clinical follow-up and immunological examination of the subjects indicated made it possible to distinguish groups with a favorable and unfavourable outcome due to the treatment carried out in the acute period. Computer processing of the immunogenetic data on the patients with TBE allowed the deriving of individual predictors of the efficacy of the symptomatic and etiotropic therapy of TBE.

[Immunogenetic methods for predicting the clinical course of tick-borne encephalitis].

Distribution of HLA antigens, haplotypes and phenotypes of the histocompatibility complex was studied and compared in 110 patients with tick borne encephalitis, living in Novosibirsk. The disease patterns and varieties were many and varied. Distribution of HLA antigens in 140 healthy subjects also living in Novosibirsk served as control.