Venous Endothelial Cell Transcriptomic Profiling Implicates METAP1 in Preeclampsia.

Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.

An Unusual Case of Sternal Osteomyelitis and Purulent Mediastinitis After a Traumatic Sternal Body Fracture.

A 67-year-old female presented to the emergency department after falling on her chest. On initial presentation, her chest wall was tender to palpation with mild overlying ecchymosis. Initial imaging demonstrated a sternal body fracture with minimal retrosternal hematoma.

You "R/R" What You Eat: Effects of High-Fiber, Low-Starch Diet Change on Regurgitation and Reingestion and Coprophagy in Zoo-Housed Gorillas.

Regurgitation and reingestion (R/R) and coprophagy are common behaviors exhibited by primates living in human care. To reduce this undesirable behavior in two troops of western lowland gorillas (Gorilla gorilla gorilla), the diet was modified by increasing fiber (by increasing browse) and decreasing starch (by reducing but not eliminating biscuits). We monitored behavior before, 3 weeks after, and 1 year after the diet change.

ARBEL: A Machine Learning Tool with Light-Based Image Analysis for Automatic Classification of 3D Pain Behaviors.

A detailed analysis of pain-related behaviors in rodents is essential for exploring both the mechanisms of pain and evaluating analgesic efficacy. With the advancement of pose-estimation tools, automatic single-camera video animal behavior pipelines are growing and integrating rapidly into quantitative behavioral research. However, current existing algorithms do not consider an animal's body-part contact intensity with- and distance from- the surface, a critical nuance for measuring certain pain-related responses like paw withdrawals ('flinching') with high accuracy and interpretability.