Driving multisectoral antimicrobial resistance action in South America: Lessons learned from implementing an enhanced tripartite AMR country self-assessment tool.

As part of an innovative Tripartite-EU collaboration Project that supports seven South American countries, a Landscape Analysis Tool (LAT) was developed and implemented to collect data to complement the Tripartite AMR Country Self-Assessment Survey (TrACSS) process. The LAT enables collection of broader and deeper information to guide development of priority One Health activities, and strengthen national action plans to combat antimicrobial resistance. The Project developed the tool, trained a consultant pool in its use, and implemented it in conjunction with multi-sectoral country teams.

Insulin and insulin like growth factor II endocytosis and signaling via insulin receptor B.

Background: Insulin and insulin-like growth factors (IGFs) act on tetrameric tyrosine kinase receptors controlling essential functions including growth, metabolism, reproduction and longevity. The insulin receptor (IR) binds insulin and IGFs with different affinities triggering different cell responses.

Results: We showed that IGF-II induces cell proliferation and gene transcription when IR-B is over-expressed.

Financing and organisation of veterinary services.

This paper analyses the different ways of financing official Veterinary Services (VS) and the effects of these choices on the performance of such Services. The links between governance, organisational effectiveness and financing arrangements are seen as particularly important. The paper comments on some of the advantages and disadvantages of financing VS with service fees, as compared to budget transfers from general government revenues.

Functional characterization of TLR4 +3725 G/C polymorphism and association with protection against overweight.

Subclinical low-grade systemic inflammation has been associated with obesity, insulin resistance and metabolic syndrome (MS). Recent studies have highlighted the role of gut microbiota in these disorders. The toll-like receptor 4 (TLR4) plays a key role in the innate immune response activation.

Splashing of liquids: Interplay of surface roughness with surrounding gas.

We investigate the interplay between substrate roughness and surrounding gas pressure in controlling the dynamics of splashing when a liquid drop hits a dry solid surface. We associate two distinct forms of splashing with each of these control parameters: Prompt splashing is due to surface roughness and corona splashing is due to instabilities produced by the surrounding gas. The size distribution of ejected droplets reveals the length scales of the underlying droplet-creation process in both cases.