Publications by authors named "L O Abrahamsson"
Information on how parental risk for posttraumatic stress disorder (PTSD) relates to their children's risk for drug use disorder (DUD) and alcohol use disorder (AUD) is limited. This study is the first to utilize an extended adoption design which can address questions about the degree of, and sources of, cross-generational and cross-disorder transmission of PTSD and substance use disorders. We examined diagnoses using Swedish National registries for parents and their adult offspring ( = 2,194,171, born 1960-1992) from six types of families (intact (1), not lived with biological father (2) or mother (3), step father (4), step mother (5), and adoptive (6)).
View Article and Find Full Text PDFBackground And Hypothesis: To clarify, in a large, representative, longitudinal sample, the rate and predictors of diagnostic conversion from Bipolar Disorder (BD) to Schizophrenia (SZ) and from SZ→BD.
Design: From individuals born in Sweden 1950-1995 and living there in 1970 or later, we identified at least one initial diagnoses of SZ (n = 8449) and BD (n = 8438) followed for a minimum of 10 and a mean of 24 years. Diagnostic conversion required, respectively, at least two final diagnoses of BD and SZ 30 days apart with no intervening diagnosis of SZ or BD.
Article Synopsis
- - The study analyzed siblings of individuals with major depression (MD) alongside control groups to examine the familial risks and clinical features of MD over several decades.
- - Results revealed a correlation (0.20) between MD in probands and their siblings, with factors like early age of onset, number of depressive episodes, and various psychiatric conditions increasing the risk of MD among siblings.
- - Siblings of MD probands showed significantly elevated risks for various disorders, including ADHD, anxiety disorders, and bipolar disorder, suggesting that familial liability for MD is influenced by genetic factors and overlaps with a range of psychiatric illnesses.
Importance: Twin studies have found that posttraumatic stress disorder (PTSD) is influenced by both genetic and environmental factors within a generation. No study has used an adoption design, which can address questions about the degree and sources of cross-generational transmission of adverse stress responses (ASRs) and PTSD.
Objectives: To examine whether ASRs or PTSD are transmitted from parents to offspring, and to clarify the relative importance of genes and rearing.