Publications by authors named "L Novakova"
Microbiology reference laboratories perform a crucial role within public health systems. This role was especially evident during the COVID-19 pandemic. In this Viewpoint, we emphasise the importance of microbiology reference laboratories and highlight the types of digital data and expertise they provide, which benefit national and international public health.
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- The study explores the Gas6/TAM receptor system's impact on neurodegeneration in multiple sclerosis (MS), focusing on how it relates to demyelination and remyelination processes.
- Researchers analyzed cerebrospinal fluid (CSF) samples from various MS patients and healthy controls to measure soluble Gas6/TAM biomarkers and assess brain volume changes over time.
- Findings suggest that elevated levels of Gas6 and its receptors correlate with greater white matter damage and that lower levels of these markers may indicate better remyelination, highlighting their potential role in MS progression.
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- The researchers successfully synthesized the natural compound prunolactone A and its unnatural epimer in 10 and 8 steps, respectively.
- The synthesis involved creating a key reactive intermediate and using a biomimetic Diels-Alder reaction to combine it with scytolide derivatives.
- Computational analysis supported the selectivity of the Diels-Alder reaction, highlighting the techniques used to achieve stereochemical purity.
Article Synopsis
- A new high-throughput UHPLC-MS/MS method was developed for profiling 38 steroid classes in biological fluids, effectively addressing previous analytical challenges.
- The method resolves 16 stereoisomers and 15 positional isomers within a 20-minute run, while minimizing sample requirements and interference from other compounds.
- This approach has been validated against international guidelines and successfully applied to analyze over 500 mouse plasma samples for various biologically active steroids.
Background: Although neuromelanin-sensitive magnetic resonance imaging (NM-MRI) has been used to evaluate early neurodegeneration in Parkinson's disease, studies concentrating on the locus coeruleus (LC) in pre-dementia stages of dementia with Lewy bodies (DLB) are lacking.
Objectives: The aims were to evaluate NM-MRI signal changes in the LC in patients with mild cognitive impairment with Lewy bodies (MCI-LB) compared to healthy controls (HC) and to identify the cognitive correlates of the changes. We also aimed to test the hypothesis of a caudal-rostral α-synuclein pathology spread using NM-MRI of the different LC subparts.