Publications by authors named "L Nivison-Smith"
Article Synopsis
- Choroidal vascularity index (CVI) is used to evaluate the choroid in various diseases, but this study focuses on its relation to natural aging by examining 309 healthy individuals aged 20 to over 70.
- The study found that CVI is highest in the central area of the retina compared to the periphery, yet it does not significantly change with age, despite certain choroidal area parameters declining as one gets older.
- This research established a normative database of CVI and other choroidal metrics, aiding in differentiating between normal aging and pathological changes in future studies.
Article Synopsis
- Static automated perimetry (SAP) is a crucial technique for evaluating visual field function in conditions like glaucoma and age-related macular degeneration, although its basic methodology has remained largely unchanged since the 1980s.
- Ongoing research is aimed at addressing issues such as optimizing testing parameters, understanding the impact of subjective responses, and aligning structural and functional assessments for better defect detection.
- The manuscript will discuss psychophysical principles, propose frameworks for improving tests, and explore methods to enhance clinical outcomes by reconciling subjective responses with objective measurements.
Retinal Pigment Epithelium Curvature Can Predict Late Age-Related Macular Degeneration.
Invest Ophthalmol Vis Sci
October 2024
Purpose: Outer retinal band integrity strongly predicts late age-related macular degeneration (AMD). However, it is often assessed subjectively as "continuity" using inconsistent definitions. Alternatively, "curvature" of the outer retinal bands is a quantitative metric that strongly correlates with AMD biomarkers and can screen for intermediate AMD.
View Article and Find Full Text PDFIntroduction: Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) is a rare genetic condition with a broad phenotypic presentation. This study aims to establish the first Australian cohort of individuals affected by CADASIL (AusCADASIL) and examine its clinical features and longitudinal course, and to investigate neuroimaging and blood biomarkers to assist in early diagnosis and identify disease progression.
Methods: Participants will be recruited from six study centres across Australia for an observational study of CADASIL.
Purpose: To determine if performing the isometric handgrip test (IHGT) can augment optical coherence tomography angiography (OCTA) vascular signal quality in eyes with macular abnormalities.
Methods: A randomized, single-blinded crossover trial was conducted including 36 participants with macular abnormalities, randomized to undergo OCTA with or without the IHGT, then crossed over to the alternate "intervention" after 1 minute. The primary outcome was OCTA signal quality after 1 minute of squeezing at 50% maximum grip strength.