Publications by authors named "L Nissinen"
Actinic keratosis and cutaneous squamous cell carcinoma in situ are precancerous forms of cutaneous squamous cell carcinoma. In this single-centre retrospective study, patients with histopathologically confirmed actinic keratosis (n = 121) or cutaneous squamous cell carcinoma in situ (n = 99) as their initial keratinocyte-derived lesion were compared and evaluated with regard to development of cutaneous squamous cell carcinoma during a 5-year observation period. Patients with severely dysplastic actinic keratosis or cutaneous squamous cell carcinoma in situ as their initial lesion developed cutaneous squamous cell carcinoma more rapidly than patients with actinic keratosis with mild or moderate dysplasia.
View Article and Find Full Text PDFArticle Synopsis
- Long non-coding RNAs (lncRNAs) are significant in the progression of cutaneous squamous cell carcinoma (cSCC), a common and aggressive skin cancer with poor prognosis and no current biomarkers for metastasis risk.
- RNA sequencing analysis revealed six gene clusters, showing that upregulated lncRNAs are linked to increased cell motility in cSCC and head and neck SCC (HNSCC).
- Specifically, higher levels of lncRNAs HOTTIP and LINC00543 were found in tumor samples and correlated with worse outcomes, suggesting these lncRNAs could serve as new biomarkers or potential targets for therapies in metastatic cSCC.
Cutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer. The incidence of cSCC is increasing globally and the prognosis of metastatic disease is poor. Currently there are no specific targeted therapies for advanced or metastatic cSCC.
View Article and Find Full Text PDFCutaneous squamous cell carcinoma (cSCC) is the most common metastatic skin cancer and the metastatic disease is associated with poor prognosis. Cancer-associated fibroblasts (CAFs) promote progression of cancer, but their role in cSCC is largely unknown. We examined the potential of CAF markers in the assessment of metastasis risk and prognosis of primary cSCC.
View Article and Find Full Text PDFBackground: Cutaneous squamous cell carcinoma (cSCC) is one of the most common and fastest increasing forms of cancer worldwide with metastatic potential. Long noncoding RNAs (lncRNAs) are a group of RNA molecules with essential regulatory functions in both physiological and pathological processes.
Objectives: To investigate the function and mode of action of lncRNA plasmacytoma variant translocation 1 (PVT1) in cSCC.