Development and validation of a risk score to predict the probability of postoperative vomiting in pediatric patients: the VPOP score.

Background: Few data are available in the literature on risk factors for postoperative vomiting (POV) in children.

Objective: The aim of the study was to establish independent risk factors for POV and to construct a pediatric specific risk score to predict POV in children.

Methods: Characteristics of 2392 children operated under general anesthesia were recorded.

Onset and persistence of respiratory/allergic symptoms in preschoolers: new insights from the PARIS birth cohort.

Background: The natural course of childhood asthma and allergy is complex and not fully understood. We aimed to identify phenotypes based upon the time course of respiratory/allergic symptoms throughout preschool years.

Methods: As part of the PARIS cohort, symptoms of wheezing, dry night cough, rhinitis and dermatitis were collected annually from birth to age 4 years.

Dry night cough as a marker of allergy in preschool children: the PARIS birth cohort.

Background: Early detection of children at risk for developing allergy is an important challenge. Our first analyses in infants from the Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort suggested that dry night cough was associated with parental-reported allergic disorders. The aim of the present study was to refine this finding by investigating the time course of dry night cough from birth to age 4 yr in relation to blood markers of atopy and allergic morbidity.

Risk factors and characteristics of respiratory and allergic phenotypes in early childhood.

Background: Unsupervised approaches can be used to analyze complex respiratory and allergic disorders.

Objective: We investigated the respiratory and allergic phenotypes of children followed in the Pollution and Asthma Risk: An Infant Study (PARIS) birth cohort.

Methods: Information on respiratory and allergic disorders, medical visits, and medications was collected during medical examinations of children at 18 months of age; biomarker data were also collected (total and allergen-specific IgE levels and eosinophilia).

Cough and dyspnoea may discriminate allergic and infectious respiratory phenotypes in infancy.

Asthma symptoms are non-specific during infancy, making the identification of different subgroups among preschool children with early respiratory manifestations an important challenge. We previously used a clustering approach to identify bronchial obstructive phenotypes in 1-yr-old infants from the Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort. In the present study, we examined whether these phenotypes were stable at 3 yr and studied their comorbidity and risk factors.