Publications by authors named "L Nigro"
Article Synopsis
- Noonan syndrome (NS) is an autosomal dominant genetic disorder affecting multiple organ systems and is often linked to a higher risk for certain cancers, particularly blood-related diseases.
- A case study is presented of a child diagnosed with transient myeloproliferative disorder at birth who later developed hyperdiploid B-cell precursor acute lymphoblastic leukemia and was found to have a specific germline mutation.
- After successful treatment and periods of remission, the same child developed juvenile myelomonocytic leukemia and received a hematopoietic stem cell transplant, prompting a review on the connection between NS and various hematological conditions.
Background: Passive-dynamic ankle-foot orthoses (PD-AFOs) are often prescribed to address plantar flexor weakness during gait, which is commonly observed after stroke. However, limited evidence is available to inform the prescription guidelines of PD-AFO bending stiffness. This study assessed the extent to which PD-AFOs customized to match an individual's level of plantar flexor weakness influence walking function, as compared to No AFO and their standard of care (SOC) AFO.
View Article and Find Full Text PDFMillion tons of tires become waste every year, and the so-called End-of-Life Tires (ELTs) are ground into powder (ELT-dp; size < 0.8 mm) and granules (ELT-dg; 0.8 < size < 2.
View Article and Find Full Text PDFAtaxia-telangiectasia (A-T) is an autosomal-recessive disorder caused by pathogenic variants (PVs) of the ATM gene, predisposing children to hematological malignancies. We investigated their characteristics and outcomes to generate data-based treatment recommendations. In this multinational, observational study we report 202 patients aged ≤25 years with A-T and hematological malignancies from 25 countries.
View Article and Find Full Text PDFCoastal waters face significant anthropogenic stress, particularly from tourism, exacerbating pollution, especially in areas like touristic islands. Ischia, the largest island in the Gulf of Naples and part of the Regno di Nettuno Marine Protected Area, suffers from pollution due to tourism and maritime traffic. During the initial SARS-CoV-2 lockdown from March to June 2020, Ischia was isolated, providing a unique opportunity to study pollutant release and its impact on coastal ecosystems.
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