Publications by authors named "L Nicole"
Customizable patterned membranes for cardiac tissue engineering: A model-assisted design method.
J Mech Behav Biomed Mater
February 2025
Myocardial infarction can cause irreversible damage to the heart muscle, which can lead to heart failure. The difficulty of the treatment mainly arises from the anisotropic behavior of the myocardium fibrous structure. Patches or cardiac restraint devices appear to be a promising approach to post-infarction treatment.
View Article and Find Full Text PDFBackground: Robotic-assisted lymphatic reconstruction has gained increasing interest over the past few years.
Objectives: The aim of this study was to systematically investigate the benefits of robotic-assisted lymphatic surgery based on currently published literature.
Methods: A systematic review evaluating the feasibility, surgical aspects, and both objective and subjective improvements in patients with impairment of the peripheral or central lymphatic system was performed according to the PRISMA guidelines.
Article Synopsis
- Lung cancer remains the leading cause of cancer mortality, but advancements in treating non-small cell lung cancer (NSCLC) have improved patient outcomes through tailored approaches using immune checkpoint inhibitors and genetic testing.
- A study was conducted across multiple pulmonary pathology units in Northern Italy, analyzing biomarker testing data for 1,817 NSCLC patients over 24 months, finding that while most had at least one test, only 36% of advanced cases underwent all five recommended tests.
- The results emphasize the need for comprehensive biomarker testing, as many early-stage patients also exhibited relevant genomic alterations, which is important for future targeted therapies.
Background: The cutoff of <1% positive cells to define estrogen receptor (ER) negativity by immunohistochemistry (IHC) in breast cancer (BC) is debated. We explored the tumor immune microenvironment and gene-expression profile of patients with early-stage HER2-negative ER-low (ER 1%-9%) BC, comparing them to ER-negative (ER <1%) and ER-intermediate (ER 10%-50%) tumors.
Methods: Among 921 patients with early-stage I-III, ER ≤50%, HER2-negative BCs, tumors were classified as ER-negative (n = 712), ER-low (n = 128), or ER-intermediate (n = 81).
Diagnosis of peripheral pulmonary lesions (PPL) is one of the most challenging fields in early lung cancer diagnosis. Despite novel techniques and new approaches to the periphery of the lung, almost 25% of PPL remains undiagnosed. Virtual bronchoscopy navigation (VBN) potentially allows to sample PPL previously not reachable with conventional bronchoscopy.
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