Publications by authors named "L Ni"

Article Synopsis
  • Mitochondrial dysfunction leads to chondrocyte aging, contributing to osteoarthritis (OA) and it remains uncertain if mesenchymal stem cells (MSCs) can help restore mitochondrial function in chondrocytes or reverse OA progression.
  • The study utilized mitochondria-rich extracellular vesicles (MEV) from stem cells to determine their impact on both healthy and stressed human articular chondrocytes in vitro, and further tested their effects in OA rats.
  • Findings revealed that MEV could enter chondrocytes, reduce oxidative stress markers, enhance mitochondrial function, and effectively reduce cartilage degeneration in OA rats, suggesting a potential therapeutic approach for OA management.
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Background: Jianwei Xiaoshi oral liquid (JWXS), a classical traditional prescription comprising various edible medicinal plants, has demonstrated significant efficacy in treating paediatric indigestion. It originates from Jianpi Pill, which is developed in the Ming Dynasty and nourishes the spleen and regulates gastrointestinal function. However, the specific molecular mechanisms involved remain unclear.

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BACKGROUND Varicella-zoster virus (VZV) encephalitis is a commonly reported form of encephalitis that clinically manifests as skin lesions, fever, headache, and neuropsychiatric symptoms. We present a case of a patient with VZV encephalitis complicated by cerebral hemorrhagic transformation, characterized by high levels of inflammation and protein in the cerebrospinal fluid. The aim is to highlight the risk of hemorrhagic transformation associated with VZV encephalitis.

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Neural precursor cells (NPCs) are a group of cells with self-renewal and multi-differentiation potential. MicroRNAs are required for neurogenesis in the central nervous system (CNS). Recent reports suggest that miR-1224 is important in human CNS diseases.

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This study aimed to examine whether an acceptance and commitment therapy (ACT)-based parenting program, incorporating topics of emotional and stress management, parenting skills training, autism-related education, and self-care learning, could be successfully implemented, well-received, and beneficial for parents of children with autism. We randomly assigned 40 parents to either participate in the eight-session ACT-based parenting program or receive usual care only. The program was found to be feasible, with many parents willing to participate and complete the sessions.

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