Markers of cartilage and bone matrix metabolism differ between the sera of macaque and squirrel monkeys.

Background: Nonhuman primates develop the characteristic lesions of osteoarthritis, making them attractive biomedical models for the study of environmental factors, such as diet, which may influence the progress of the condition.

Methods And Materials: We used ELISA assays of potential markers of osteoarthritis which were developed for use in humans to see if we could determined the presence of immunoreactivity in two nonhuman primate genera - Macaca (macaque monkeys) and Saimiri (squirrel monkeys).

Results: Inter-generic differences were significant for most markers.

Visceral adiposity is an independent predictor of incident hypertension in Japanese Americans.

Background: Visceral adiposity is generally considered to play a key role in the metabolic syndrome.

Objective: To examine the relationship between directly measured visceral adiposity and the risk for incident hypertension, independent of other adipose depots and fasting plasma insulin levels.

Design: Community-based prospective cohort study with 10- to 11-year follow-up.

Visceral adiposity and the prevalence of hypertension in Japanese Americans.

Background: Visceral adiposity is generally considered to play a key role in the metabolic syndrome, including hypertension. The purpose of this study was to evaluate cross-sectionally whether visceral adiposity is associated with prevalence of hypertension independent of other adipose depots and fasting plasma insulin.

Methods And Results: Study subjects included 563 Japanese Americans with normal or impaired glucose tolerance or diabetes but not taking oral hypoglycemic medication or insulin at entry.

Visceral adiposity and the risk of impaired glucose tolerance: a prospective study among Japanese Americans.

Objective: Greater visceral adiposity, higher insulin resistance, and impaired insulin secretion increase the risk of type 2 diabetes. Whether visceral adiposity increases risk of impaired glucose tolerance (IGT) independent of other adipose depots, insulin resistance, and insulin secretion is not known.

Research Design And Methods: Study subjects included 128 Japanese Americans with normal glucose tolerance at entry.

Spinal degenerative disk disease (DDD) in female macaque monkeys: epidemiology and comparison with women.

Spinal degenerative disk disease (DDD) in a radiographic, cross-sectional sample of 192 female macaque monkeys, approximately 5-30 years old, is described. The presence and extent of disk space narrowing (DSN) and anterior osteophytosis were assessed with reference to age, average lifetime body mass. and distribution within the thoracolumbar spine.