The mode of antibacterial action of the novel agent ZM240304 (D-arabino-2,3,4-tris(4-chlorobenzyl) pentane-1,5-diamine).

ZM240304 is an example of a new class of antibacterial agents that is active against experimental infections in animals. The compound was demonstrated to be a membrane-active compound that disrupted the outer membrane of Gram-negative organisms and allowed the leakage of periplasmic enzymes. Respiration was inhibited and cellular ATP levels were reduced, leading to cell death.

The membrane destabilising action of the antibacterial agent chlorhexidine.

The antibacterial agent chlorhexidine has long been used as an agent for medical antisepsis. This compound is a membrane active agent which probably has its major antibacterial action by interference with the function of cellular membranes. The results demonstrated an inhibition of oxygen utilisation by bacteria which was related to falls in cellular ATP levels.

Biochemical changes associated with the antifungal action of the triazole ICI 153,066 on Candida albicans and Trichophyton quinckeanum.

The triazole antifungal agent, ICI 153,066, acts on Candida albicans and Trichophyton quinckeanum by inhibiting demethylation of the sterol ring. In C. albicans this is at the level of lanosterol whereas in T.

The effects of 50 Hz magnetic fields on opioid peptide mediated inhibition of guinea pig ileum.

Strips of guinea pig ileum were mounted in a tissue bath within the poles of a magnet capable of generating a 50 Hz field of intensity up to 1 mT. In the absence of magnetic field the preparations were stimulated transmurally at tetanic frequency (10 Hz). The post-tetanic inhibition was antagonised by naloxone.