Outcome of Patients With Central Nervous System Multiple Myeloma (CNS-MM) Treated With CNS-Directed Radiation Therapy.

Background: The prognosis of multiple myeloma involving the central nervous system (CNS-MM) is poor. We report outcomes of CNS-MM treated with CNS-directed radiation therapy (RT).

Methods: We retrospectively reviewed patients with CNS-MM treated with CNS-directed RT from 2015 to 2024.

Mechano-dependent sorbitol accumulation supports biomolecular condensate.

Condensed droplets of protein regulate many cellular functions, yet the physiological conditions regulating their formation remain largely unexplored. Increasing our understanding of these mechanisms is paramount, as failure to control condensate formation and dynamics can lead to many diseases. Here, we provide evidence that matrix stiffening promotes biomolecular condensation in vivo.

Ultra-Low-Dose Radiation for Extranodal Marginal Zone Lymphoma of the Lung.

Purpose: Definitive intent radiation therapy (RT) for early-stage mucosa-associated lymphoid tissue (MALT) lymphoma typically includes a dose of 24 to 30 Gy. While modest, these doses may have associated toxicity. For patients with indolent B-cell lymphoma, there is increasing support for the use of ultra-low-dose RT (ULDRT) using 4 Gy in 2 fractions as part of a response-adapted approach, as high rates of complete response have been documented.

How we manage multiple myeloma with clonal hematopoiesis of indeterminate potential (CHIP): a case report.

Background: Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by genetic alterations associated with hematologic neoplasms, posing clinical challenges in managing concurrent hematological malignancies. CHIP may complicate the treatment landscape due to its potential to influence disease progression and treatment response. We report a 73-year-old male with multiple myeloma (MM) harboring a CHIP PPM1D mutation, elucidating the complexities and therapeutic considerations in such cases.

Effect of stabilization of patients on the accuracy and scanning time of maxillary dentate quadrants: A clinical study.

Statement Of Problem: As intraoral scanning has gained widespread acceptance as an alternative to conventional impression-making, numerous studies have evaluated the influence of operator-related factors and patient-related factors on scanning accuracy. While several authors have noted patient movements as a clinical limitation of scanning technologies, research providing empirical data or testing this hypothesis is lacking.

Purpose: The purpose of this clinical study was to assess the effect of using the Zero Motion Scanning Band, a silicone occlusal mouth prop, and an OptraGate lip retractor for stabilizing the head and jaw on the accuracy (trueness and precision) and scanning time of digital quadrant scans.