[Indexes of local cytokine status in individuals with intestine dysbacteriosis].

Aim: Determination of the content of various cytokines in coprofiltrates of individuals with bacteriologically confirmed intestine dysbacteriosis.

Materials And Methods: Qualitative and quantitative content of large intestine microbiocenosis was studied; IFNγ, pro-inflammatory (IL-2, IL-6, IL-8, IL-1β) and anti-inflammatory (IL-4, IL-10) content was determined using EIA in coprofiltrates of 139 individuals aged 18 - 60 years. All the indexes were juxtaposed with the cytokine index (CI): RESULTS.

[Indexes of immunity and local protection in humans with intestine dysbacteriosis].

Aim: Study indexes of immunity and local protection in humans with intestine dysbacteriosis.

Materials And Methods: Qualitative and quantitative intestine microbiocenosis, content of gamma-interferon (EIA method) in coprofiltrates in 204 individuals were studied, data from immunograms of 123 individuals with bacteriologically confirmed dysbacteriosis were analyzed.

Results: The presence of immune deficiency mainly by T-cell type was established in 92.

[Features of microbiocenosis composition of large intestine of humans with various degree of local metabolic disorders].

Aim: Detection of features of qualitative and quantitative composition of large intestine microbiocenosis of humans with various degree of local metabolic disorders during dysbacterioses due to various causes.

Materials And Methods: Microflora of large intestine and content of malonic dialdehyde (MDA) in coprofiltrates of 330 adult humans with large intestine dysbacterioses due to various causes were studied.

Results: It was established, that high MDA content in coprofiltrates matches higher quantities of opportunistic microorganisms and atypical escherichia in microflora composition of large intestine.

[Biochemical criteria for severity of colonic dysbacteriosis].

The purpose of the investigation was to estimate the content of malondialdehyde (MDA) in the coprofiltrates of human beings with bacteriologically verified colonic dysbacteriosis and to clarify a relationship of the amount of MDA in the coprofiltrates to the degree of the abnormal qualitative and quantitative composition of microbiocenosis. Specimens from 109 subjects aged 19 to 56 years were examined. The change in the level of MDA in the coprofiltrates was found to correspond to the impairment in the composition of microbiocenosis.