[Characteristics of the microcirculation and blood rheology in arterial and venous forms of mesenteric vascular occlusion].

The functional properties of microcirculation and rheology of blood were studied in dogs subjected to arterial and venous occlusion of mesenteric vessels (cranial mesenteric artery and cranial mesenteric vein). It was found that a local alterations of microvascular bed of intestinal wall are quite different in case of arterial or venous occlusion. The degree of hemorheological and microvascular deviations is higher in case of acute venous thrombosis than during the acute occlusion of cranial mesenteric artery.

[Prevention by alpha and beta adrenoreceptor agonists and lithium hydroxybutyrate of injuries to the endothelium of the rabbit aorta induced by catecholamines].

The damage of endothelial cells and intercellular junctions caused by 10 microM epinephrine (E) and 10 microM norepinephrine (NE) has been observed in perfused rabbit aorta. Simultaneous perfusion of the rabbit aorta with E and NE induced marked endothelial injuries at very low drug doses (0.1 microM).

[Change in the morphology and permeability of perfused rabbit arteries in the phase of acute elevation of intravascular pressure].

Morphological changes of the endothelium were induced by acute elevation of intravascular pressure in the normal perfused rabbit aorta from 100 to 250 mm Hg. The number of argyrophilic cells and stigmata per 1 mm2 of the luminal surface has significantly increased. The acute rise in intravascular pressure was followed by a 2-fold and 20-fold increase in the uptake of 125I-labelled low density lipoproteins in intact endothelial areas and denudation areas, respectively.