Publications by authors named "L N Sepeta"
Article Synopsis
- Right and bilateral language representation in focal epilepsy may be influenced by seizure activity and lesions in the left hemisphere, with research suggesting that earlier seizure onset could lead to atypical language lateralization due to childhood brain plasticity.
- A meta-analysis examined the link between age at seizure onset and language lateralization using fMRI, finding a small but significant correlation (r=0.1, p=.005) between earlier onset and rightward lateralization across various samples.
- The study concluded that while there is a slight association consistent with theories of declining language plasticity, this relationship is subtle and not a reliable indicator of atypical language lateralization for individual patients.
In this article, we provide an overview of our panel presentation at the American Epilepsy Society meeting in December2023. Our presentation reviewed functional mapping methods for epilepsy surgery including well-established and newer methods, focusing mostly on language and memory. Dr Leigh Sepeta (Chair) and Dr Jana Jones (Chair) organized the presentation, which included 5 presenters.
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- * Researchers used advanced imaging techniques to analyze how different parts of the hippocampus connect with specific cortical pathways during brain development, with the front part linked to the anterior temporal pathway and the back part to the posterior medial pathway.
- * The study found that as brains develop, there is a shift in connectivity from the back to the front of the hippocampus, emphasizing its role in episodic memory and identifying key regions that influence how the hippocampus integrates into broader brain functions.
Article Synopsis
- * It found some kids are really good at broad language skills, but struggle more with reading fluency and comprehension.
- * Certain factors, like the age when seizures start and how many medicines they take, can affect these language and reading abilities in kids with epilepsy.
Background: Isolated psychiatric symptoms can be the initial symptom of pediatric anti-N-methyl-d-aspartate (NMDA) receptor autoimmune encephalitis (pNMDARE). Here we report on the prevalence of isolated psychiatric symptoms in pNMDARE. We also assess whether initial neurodiagnostic tests (brain magnetic resonance imaging [MRI], electroencephalography [EEG], and/or cerebrospinal fluid [CSF] white blood cell count) are abnormal in children with isolated psychiatric symptoms and pNMDARE.
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