[Chromosomal changes in primary myelodysplasias].

The data from literature on chromosome abnormalities in various subgroups of the myelodysplastic syndrome (according to FAB-classification) are presented. Special attention is paid to information about changes in the number and structure of chromosomes during the disease and their prognostic significance. The relation of definite chromosome aberrations to the clinical course and prognosis of the disease, in particular to its transformation into acute leukosis is under discussion.

[3 clinico-hematologic variants of hairy-cell leukemia].

Analysis of the disease course in 17 patients afflicted with hairy-cell leukemia enabled the authors to specify 3 clinico-hematologic variants of the disease: a typical or a splenic one (with a predominant injury to the spleen), an atypical or bone marrow one (with a predominant injury to bone marrow), and a hypoplastic one. The bone marrow variant was characterized by the most pronounced leukemic injuries to bone marrow, severe bacterial complications, and the most unfavourable prognosis. The remaining variants were marked by their own individual features and ran a more favourable course.