Publications by authors named "L N Nwosu"

Corruption, a global phenomenon, affects countries worldwide, transcending geographic and political boundaries, and continues to escalate, partly due to the inefficiency of financial and legal institutions and lack of enforcement. This has significant implications for Africa, hindering democracy, development, and poverty alleviation efforts. Defined as the intentional misuse of official authority for personal benefit, corruption is often fueled by public sector financial managers or accounting officers embezzling funds.

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Phage-derived bacteriocins (tailocins) are ribosomally synthesized structures produced by bacteria in order to provide advantages against competing strains under natural conditions. Tailocins are highly specific in their target range and have proven to be effective for the prevention and/or treatment of bacterial diseases under clinical and agricultural settings. We describe the discovery and characterization of a new tailocin locus encoded within genomes of and subsp.

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Article Synopsis
  • The study explores the role of microRNA-155 (miR-155) in rheumatoid arthritis (RA), specifically how its increased expression may hinder monocyte polarization into anti-inflammatory macrophages.
  • Researchers tested the therapeutic effects of antagomiR-155-5p, a molecule designed to inhibit miR-155, using PEGylated liposomes in two mouse models of RA.
  • Results showed that injecting these liposomes reduced arthritis symptoms and improved the differentiation of bone marrow monocytes into anti-inflammatory macrophages, indicating a potential treatment strategy for RA in humans.
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A near-surface resistivity investigation was undertaken to investigate soil contamination and aquifer vulnerability due to leachate percolation in a major dumpsite in Calabar. The study was undertaken using 2-D electrical resistivity tomography (ERT) and vertical electrical sounding. Ten traverse lines were created within and outside the dumpsite and geo-electric measurement was conducted using dipole-dipole and Schlumberger electrode configurations.

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