Eosinophil-induced adverse events induced by treatment with programmed cell death 1/ligand 1 inhibitors: A comprehensive disproportionality analysis of the FDA adverse event reporting system.

Eosinophil-induced adverse events (Eo-irAEs) have been observed in patients treated with programmed cell death 1/ligand 1 (PD-1/PD-L1) inhibitors. Surprisingly, the clinical features and outcomes of Eo-irAEs induced by PD-1/PD-L1 inhibitors have not yet been elucidated. This study investigated the characteristics of and risk factors for Eo-irAEs induced by PD-1/PD-L1 inhibitors.

Novel Thermosensitive Hydrogel Encapsulated Carvedilol for the Treatment of Rosacea.

Background: Carvedilol can be used in the treatment of rosacea. However, their oral administration often results in a series of adverse effects.

Purpose: A novel thermosensitive hydrogel was developed to improve the administration of carvedilol in the treatment of rosacea and to evaluate its safety and efficacy.

Trophic transfer efficiency of microbial food webs differs in water and sediment in alpine wetlands across the Tibetan Plateau.

The Tibetan Plateau contains the world's largest area of alpine wetlands, where coexisting water and sediment environments provide habitats for multitrophic microbial communities. However, the microbial food web (MFW) of coexisting water and sediment in wetland ecosystems and their responses to environmental changes remain unclear. In this study, we investigated MFWs (including archaea, bacteria, and eukaryotes) across 21 paired samples from alpine wetlands on the Tibetan Plateau along a salinity gradient.

Prospective cohort study of Suture-Line recurrence and clinical outcomes in stage 1A Non-Small cell lung cancer.

Background: Increased lung cancer screening has made early-stage non-small-cell lung cancer (NSCLC) more common, with lung-sparing surgery as the standard curative treatment. Our study evaluated patients who underwent surgery for pathologic stage 0/1A NSCLC and presented with suture-line recurrences-either isolated or with additional findings-and compared these patients to other types of recurrence.

Methods: We analyzed 653 patients with pathologic stage 0/1A NSCLC from the IELCART cohort (2016-2023).

Pathogen-derived glyoxylate inhibits Tet2 DNA dioxygenase to facilitate bacterial persister formation.

Pathogenic bacterial persistence enables survival during antibiotic treatment, leading to treatment failure and recurrent infections, yet its underlying mechanisms remain unclear. Here, we reveal that glyoxylate, a metabolite originally evolved for alternative carbon utilization, functions as a signaling molecule to reprogram the host transcriptome and promote persister formation. Glyoxylate inhibits the DNA dioxygenase TET2, suppressing pro-inflammatory gene expression and attenuating host immune defense.