Publications by authors named "L N Kjaer"

Highly pathogenic avian influenza (HPAI) is a major concern in terms of animal and human health. Between October 2020 and September 2023, there were 36 HPAI outbreaks detected in poultry and other captive birds in Denmark. However, it is often not possible to determine the exact route of introduction.

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Background: The JAK2V617F mutation is a driver of Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) and is also implicated in cardiovascular diseases. Thrombosis in MPN involves JAK2V617F-associated platelet activation and endothelial dysfunction, all potentially influenced by chronic inflammation. Whether the mutation affects thromboinflammatory markers similarly in non-MPN patients remains unclear.

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Background: Alpha-gal syndrome is a novel food allergy to the oligosaccharide galactose-α-1,3-galactose (alpha-gal) present in mammalian meat. Tick bites are considered an important route of sensitization to alpha-gal. Data on alpha-gal sensitization in the general population is scant.

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Article Synopsis
  • The COMBI II clinical trial evaluated the safety and efficacy of combining ruxolitinib and low-dose pegylated interferon alfa-2a in 25 patients with newly diagnosed polycythemia vera (PV) over two years.
  • The results showed a high peripheral blood cell count remission rate of 92% and 56% of patients meeting remission criteria, with notable improvements in symptoms like abdominal discomfort and night sweats.
  • Additionally, the treatment significantly decreased the JAK2V617F variant allele frequency, with 60% of patients achieving molecular remission, indicating effective outcomes with manageable toxicity.
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