[The development of portal hypertension and liver failure on the background of long-term intake of vitamin A in a young woman. Case report].

The use of over-the-Counter (OTC) pharmaceuticals is a common phenomenon in today's society. We present a case of liver injury associated with long-term OTC use of vitamin A. The young patient took daily up to 15 capsules of a combined preparation for 2 years containing retinol palmitate 55 mg (100,000 IU) + Alpha-Tocopherol acetate 100 mg, the content of vitamin A in which significantly exceeded the recommended daily dose.

Effectiveness of indapamide/amlodipine single-pill combination in patients with isolated systolic hypertension: post-hoc analysis of the ARBALET study.

Background: This study evaluated the effectiveness of treatment with an indapamide/amlodipine single-pill combination (SPC) in outpatients with uncontrolled isolated systolic hypertension (ISH) aged over 55 years in real-life clinical practice.

Methods: This was a post-hoc analysis of the subgroup of patients with ISH from ARBALET, a 3-month, multicenter, observational, open-label study conducted in Russia among patients with grade I or II hypertension who were either uncontrolled on previous antihypertensive treatment or treatment-naïve. The effectiveness of indapamide/amlodipine SPC was assessed by the change in office systolic blood pressure (SBP) and the rate of target SBP (< 140 mmHg) achievement at 2 weeks, 1 month and 3 months, in four age groups: 55-59 years, 60-69 years, 70-79 years, and 80 years or older.

[Clinical and radiological quality assessment of root canal treatment].

The aim of the study was to assess the quality of endodontic therapy and estimate further treatment needs. Nine hundreds orthopantomograms of 442 men and 458 women (aged 18-70) without any clinical manifestations of endodontic pathology were examined. In 1170 patients (41%) additional intraoral radiographs were taken to assess the periapical status.

[Postobturation pain associated with endodontic treatment].

Postobturation pain of different origin after endodontic treatment was studied in 100 patients after treatment of 151 teeth with filling of 264 channels. 34.4% patients complained of pain.