Targeted proteomics for the analysis of cultural heritage: application of broadband collision-induced dissociation mass spectrometry.

A broadband collision-induced dissociation (bbCID) fragmentation mode was proposed for liquid chromatography-mass spectrometric targeted analysis of tryptic peptides obtained from proteins in samples of decoration paint coating. In this approach, a mass spectrometric dataset contains the information on the parent and all fragment ions. This maintains a balance between the quantity of simultaneously acquired data and the sensitivity of the method, which is beneficial under coupling with analytical chromatography.

[Dynamics of quality-of-life in patients with torticollis treated with botulinum toxin A].

Parameters of quality of life (QOL) measured with the SF-36 questionnaire were studied in 91 patients with torticollis (ST) treated with botulinum toxin A. A control group comprised 50 subjects without ST. The QOL parameters were lower in patients compared to controls.