[Efficacy of a preparation based on Lactobacillus acidophilus for protection from myelotoxic effects of ionizing radiation and antineoplastic cytostatics].

The ability of a Lactobacillus acidophilius (LA) based preparation to prevent from a myelotoxic damage was studied on (CBA.C57BL/6)F1 mice upon total gamma-irradiation or single intraperitoneal injection of cyclophosphan. The antitumor and antimetastatic activity of LA-based preparation was studied in experiments with C57BL/6 mice bearing Lewis lung carcinoma or melanoma B16.

[Study of the possibility of hyperparathyroidism development in rats exposed to internal irradiation by iodine radioisotope].

The possibility of hyperparathyroidism development secondary to earlier internal irradiation with radioactive iodine was studied experimentally in Wistar rats. This report describes the parathyroid morphology and biochemical findings for animals irradiated with 131I at the doses of 4.5, 40, or 80 Gy.

[Antitoxic features of magnesium oxide under combined radiation and thermal injury].

Male Wistar rats were exposed to 7.5 Gy total body gamma radiation followed to the additional full-thickness thermal bum. It was shown, that single administration of magnesium oxide in 1 hour after combined injury significantly corrected the early signs of endogenous intoxication.

[The modifying influence of thermal injury on the postradiation changes in the biochemical and functional activities of peritoneal macrophages].

The effect of thermal injury on radiation-induced (3-7 Gy) changes in quantitative and qualitative composition, biochemical and functional activity of the peritoneal macrophages was studied. The reduce of peritoneal cells total number and alterations of their qualitative composition were conditioned by radiation component of combined radiation end thermal injury (CRTJ). The enzymes' activity and the protein content in macrophages were the most enhanced 7-9 days after CRTJ as compared with the effect of radiation per se.

[Post-irradiation changes of metabolic and functional activity of adhesive macrophages].

Research into dose- and time-dependent alterations of quantitative and qualitative composition of the peritoneal cells has been carried out. Exposure at 3, 5, 7, or 9 Gy reduced the total number of peritoneal cells, increased the activity of the lactate-, malate-, and qlucoso-6-phosphate dehydrogenases, of the acid phosphatase and catepsin D; the amount of the cell protein in adhesing macrophages was also increased. The exposed macrophages showed enhanced phagocytic and cytotoxic activity as evidenced by the increase in luminol- and lucigenin-enhanced chemilumenscence in vitro.