Our previous study demonstrated a selective drop of pH, PO2 and blood flow in tumours under induced hyperglycaemia that enhanced the antitumour effect of hyperthermia. However, there are contraindications restricting the use of hyperglycaemia. Cryotreatment, as a method of altering tumour microphysiology similar to hyperglycaemia, was investigated.
View Article and Find Full Text PDFMed Oncol Tumor Pharmacother
March 1991
In order to clarify the influence of induced hyperglycemia upon antitumor effects of chemotherapy we studied some animal and human tumors. We observed that hyperglycemia enhances the antitumor effects of some cytostatic drugs several fold, due in part to the changes in the microphysiology induced by the hyperglycemia. Time doubling of some transplanted rat tumors and survival time of rats, rabbits and dogs bearing the transplanted and spontaneous tumors increased two to ten fold when the chemotherapy was used under hyperglycemia.
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