Publications by authors named "L Murrell"

Background: Gastrointestinal (GI) infections affect one in five people in the UK and local authorities play a crucial role in controlling these infections. However, there have been substantial reductions in funding for environmental and regulatory (ER) services that enable GI infectious disease prevention and control via food safety and infection control (FSIC) services. This study investigates how local funding cuts to these services have varied across England to understand the potential consequences of inequalities in GI infections.

View Article and Find Full Text PDF

Background: Gastrointestinal (GI) infections result in 17 million cases annually, with foodborne illness costing the National Health Service (NHS) £60m per year. The burden of GI infection is unequally distributed, with greater impact in more socioeconomically disadvantaged groups and areas. Local authorities (LA) provide vital services that protect public health and wellbeing.

View Article and Find Full Text PDF

Phosphate-based glasses (PBGs) are promising materials for bone repair and regeneration as they can be formulated to be compositionally similar to the inorganic components of bone. Alterations to the PBG formulation can be used to tailor their degradation rates and subsequent release of biotherapeutic ions to induce cellular responses, such as osteogenesis. In this work, novel invert-PBGs in the series xPO·(56 - )CaO·24MgO·20NaO (mol%), where is 40, 35, 32.

View Article and Find Full Text PDF

Phosphate-based glasses (PBGs) offer significant therapeutic potential due to their bioactivity, controllable compositions, and degradation rates. Several PBGs have already demonstrated their ability to support direct cell growth and in vivo cytocompatibility for bone repair applications. This study investigated development of PBG formulations with pyro- and orthophosphate species within the glass system (40 - x)PO·(16 + x)CaO·20NaO·24MgO (x = 0, 5, 10 mol%) and their effect on stem cell adhesion properties.

View Article and Find Full Text PDF